Carmen Domene, University of Bath, UK
Ion channels are ubiquitous membrane-embedded transport proteins crucial for life. The central function of ion channels lies on their ability to selectively transport ions given the appropriate stimuli e.g. voltage, mechanical force, temperature or pH, and provided their regulatory gates are open. Gating mechanisms can be further modulated by ligands, a fact consistent with the fine tuning of their activity to molecular cues and organism demands.