Wednesday, May 17 2017

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Membrane curvature has developed into a forefront of membrane biophysics. Numerous proteins involved in membrane curvature sensing and membrane curvature generation have recently been discovered, including proteins containing the crescent-shaped BAR domain as membrane binding and shaping module. Accordingly, the structure of these proteins and their multimeric complexes is increasingly well-understood. Substantially less understood, however, are the detailed mechanisms of how these proteins interact with membranes in a curvature-dependent manner.